Useful synthetic reagents derived from 1-triisopropylsilylpropyne and 1,3bis-[triisopropylsilyl]propyne, direct, stereoselective synthesis of either Z or E enynes

  • Elias James Corey
  • , Christoph Rücker

Research output: Journal contributionsJournal articlesResearchpeer-review

146 Citations (Scopus)

Abstract

Lithio reagents derived from 1-triisopropylsilylpropyne (1) and 1,3-bis-[triisopropylsilyl]propane (3) are effective for the synthesis of Z or E terminal enyne units (CHCHCCH) and for carboncarbon bond formation with halides, aldehydes, ketones, epoxides, and α,β-enones.

Original languageEnglish
JournalTetrahedron Letters
Volume23
Issue number7
Pages (from-to)719-722
Number of pages4
DOIs
Publication statusPublished - 1982
Externally publishedYes

Bibliographical note

Funding Information:
cyclohexyl . The erythro stereochemistry of the adduct 8 was supported by (1) the pmr spectrum

Research areas and keywords

  • Chemistry

ASJC Scopus Subject Areas

  • Organic Chemistry
  • Drug Discovery
  • Biochemistry

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