Photo-degradation of the antimicrobial ciprofloxacin at high pH: identification and biodegradability assessment of the primary by-products

Tibiriça G.  Vasconcelos; Danielle M Henriques; Armin König; Ayrton F Martins; Klaus Kümmerer

doi:10.1016/j.chemosphere.2009.03.022

Photo-degradation of the antimicrobial ciprofloxacin at high pH: identification and biodegradability assessment of the primary by-products

Tibiriça G. Vasconcelos
, Danielle M Henriques
, Armin König
, Ayrton F Martins
, Klaus Kümmerer

Research output: Journal contributions › Journal articles › Research › peer-review

190 Citations (Scopus)

Abstract

Photo-treatment for the removal of pharmaceuticals in effluents is a topic currently under discussion. In some countries effluents from hospitals are directly emitted into open ditches without any further treatment and with very little dilution. Under such circumstances photo-degradation in the environment can occur. However, photo-degradation does not necessarily end up with the complete mineralization of a chemical. Therefore, photo-product biodegradability and toxicity against environmental bacteria is of interest. Hospital effluents have often a pH around 9. Therefore, photo-oxidation (150 W medium-pressure Hg-lamp, batch reactor) of ciprofloxacin (CIP) was studied at pH 9. The primary elimination of CIP was monitored and structures of photo-products were assessed by liquid chromatography ion trap mass spectrometry (LC-MS/MS). Five compounds were identified as probable products of photo-defluorination, -decarboxylation and loss of the piperazine moiety. These photo-products were not biodegradable in the Closed Bottle test - OECD 301D. They did not affect Vibrio fisheri in the applied concentrations. © 2009 Elsevier Ltd. All rights reserved.

Original language	English
Journal	Chemosphere
Volume	76
Issue number	4
Pages (from-to)	487-493
Number of pages	7
ISSN	0045-6535
DOIs	https://doi.org/10.1016/j.chemosphere.2009.03.022
Publication status	Published - 01.07.2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research areas and keywords

Chemistry
Anti-Infective Agents
Chromatography, High Pressure Liquid
Ciprofloxacin
Environmental Pollutants
Environmental Remediation
Hydrogen-Ion Concentration
Kinetics
Photolysis
Tandem Mass Spectrometry

ASJC Scopus Subject Areas

Health, Toxicology and Mutagenesis
Pollution
Chemistry(all)
Environmental Engineering
Public Health, Environmental and Occupational Health
Environmental Chemistry

Access to Document

10.1016/j.chemosphere.2009.03.022

Cite this

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title = "Photo-degradation of the antimicrobial ciprofloxacin at high pH: identification and biodegradability assessment of the primary by-products",

abstract = "Photo-treatment for the removal of pharmaceuticals in effluents is a topic currently under discussion. In some countries effluents from hospitals are directly emitted into open ditches without any further treatment and with very little dilution. Under such circumstances photo-degradation in the environment can occur. However, photo-degradation does not necessarily end up with the complete mineralization of a chemical. Therefore, photo-product biodegradability and toxicity against environmental bacteria is of interest. Hospital effluents have often a pH around 9. Therefore, photo-oxidation (150 W medium-pressure Hg-lamp, batch reactor) of ciprofloxacin (CIP) was studied at pH 9. The primary elimination of CIP was monitored and structures of photo-products were assessed by liquid chromatography ion trap mass spectrometry (LC-MS/MS). Five compounds were identified as probable products of photo-defluorination, -decarboxylation and loss of the piperazine moiety. These photo-products were not biodegradable in the Closed Bottle test - OECD 301D. They did not affect Vibrio fisheri in the applied concentrations. {\textcopyright} 2009 Elsevier Ltd. All rights reserved.",

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T1 - Photo-degradation of the antimicrobial ciprofloxacin at high pH: identification and biodegradability assessment of the primary by-products

AU - Vasconcelos, Tibiriça G.

AU - Henriques, Danielle M

AU - König, Armin

AU - Martins, Ayrton F

AU - Kümmerer, Klaus

PY - 2009/7/1

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AB - Photo-treatment for the removal of pharmaceuticals in effluents is a topic currently under discussion. In some countries effluents from hospitals are directly emitted into open ditches without any further treatment and with very little dilution. Under such circumstances photo-degradation in the environment can occur. However, photo-degradation does not necessarily end up with the complete mineralization of a chemical. Therefore, photo-product biodegradability and toxicity against environmental bacteria is of interest. Hospital effluents have often a pH around 9. Therefore, photo-oxidation (150 W medium-pressure Hg-lamp, batch reactor) of ciprofloxacin (CIP) was studied at pH 9. The primary elimination of CIP was monitored and structures of photo-products were assessed by liquid chromatography ion trap mass spectrometry (LC-MS/MS). Five compounds were identified as probable products of photo-defluorination, -decarboxylation and loss of the piperazine moiety. These photo-products were not biodegradable in the Closed Bottle test - OECD 301D. They did not affect Vibrio fisheri in the applied concentrations. © 2009 Elsevier Ltd. All rights reserved.

KW - Chemistry

KW - Anti-Infective Agents

KW - Chromatography, High Pressure Liquid

KW - Ciprofloxacin

KW - Environmental Pollutants

KW - Environmental Remediation

KW - Hydrogen-Ion Concentration

KW - Kinetics

KW - Photolysis

KW - Tandem Mass Spectrometry

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Photo-degradation of the antimicrobial ciprofloxacin at high pH: identification and biodegradability assessment of the primary by-products

Abstract

UN SDGs

Research areas and keywords

ASJC Scopus Subject Areas

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